Tag genetics

Does This Post Make My Ass Look Big?

Why, yes, I *am* fat, thank you for noticing. Did I mention that you smell funny?

New York Times medical writer and author Gina Kolata has just published a new book entitled “Rethinking Thin: The New Science of Weight Loss — and the Myths and Realities of Dieting”, and the NYT was so kind as to run this excerpt of her book today. The excerpt presents some of the research that makes the claim that genetics influence our ability to gain, lose and maintain weight to such an extent that it is almost impossible to control your weight through diet and exercise unless you do it constantly.

There is a reason that fat people cannot stay thin after they diet and that thin people cannot stay fat when they force themselves to gain weight. The body’s metabolism speeds up or slows down to keep weight within a narrow range. Gain weight and the metabolism can as much as double; lose weight and it can slow to half its original speed.

The scientists summarized it in their paper: “The two major findings of this study were that there was a clear relation between the body-mass index of biologic parents and the weight class of adoptees, suggesting that genetic influences are important determinants of body fatness; and that there was no relation between the body-mass index of adoptive parents and the weight class of adoptees, suggesting that childhood family environment alone has little or no effect.”

In other words, being fat was an inherited condition.

A new study conducted by Harvard Medical School finds that different kinds of body fat have different effects on a person’s overall health, according to this BBC story. Subcutaneous fat — the kind that Sir Mix-A-Lot loves — actually produces hormones called “adipokines” (literally, “fat movers”) that can increase metabolism and can aid in insulin receptivity, thus reducing the risk of diabetes. Visceral fat — the All-American Beer Belly — does not have any beneficial effect.

Another new study, this one conducted at the Karolinska Institute in Sweden, found that fat cells in the human body actually replace themselves over time, just like other cells. It was previously thought that this did not occur. (It has also recently been discovered that brain cells also replace themselves, which was thought to be impossible as well. Maybe that explains the large number of fat-heads in our society…but I digress…) Even in gastric-bypass patients, while the fat cells shrank, the number of fat cells in their bodies did not actually decrease. That ties in pretty well with the idea that your overall tendency toward obesity is genetic and your ability to maintain a lower weight (if you’re overweight like me) is hard to achieve.

At least, that’s my story and I’m sticking to it.

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Sci-Tech Link Dump

Time again to blow through a bunch of assorted but unconnected links to things I’ve read in the science and tech worlds recently:

Mother Jones magazine featured this quasi-interview with MythBuster Jamie Hyneman about alternative energy technologies. I say “quasi-interview” because his responses to their questions are so terse that it’s hard to tell if he actually said them or not, except that Jamie is rather short-spoken in the first place. The piece says that he’s really into alt-energy, and on the show the MythBusters have repeatedly demonstrated that most of the “free energy” stuff you see is total hogwash. Something to think about, since this morning everybody has a link to this “$1/gal Ethanol” story in Popular Mechanics.

RetroThing had me all nostalgic the other day for the very first computer I ever owned, the Sinclair ZX81. Mine was not a kit, it came fully-assembled. I bought it second-hand from my high-school best friend Andy, who had moved on to such cutting edge technology of the day as the TRS-80. It even came with the add-on 16K memory module. The post includes a link to this page which tells you how to build your own ZX80/81 with a couple dozen ICs and a circuit board, but if you don’t feel like building one, you can just download an emulator here.

The science journal Nature has this news article about understanding metabolism as a genetic condition. British researchers re-used some urine samples originally collected for another study and used a new form of spectroscopy to completely identify all the chemicals in the samples. They then identified the geographies of the test subjects and graphed specific metabolites and were able to determine that different populations have unique metabolic rates. People in Southern China, they conclude, have the best metabolisms in the world. People in South Texas have the worst metabolisms in the world. Yet more scientific evidence as to why one should stay away from Texas, if you ask me.

You knew I would have at least ONE nanotech link, right? Of course right! Today’s nano-news is this bulletin that tries to sex up the story with the headline “Nanotechnology paves way for super iPods”. Nice try. The underlying story is that a team at University of Glasgow have figured out how to make molecule-sized switches, which in turn will allow for as many as 1 billion transistors to fit on a single chip (up from 200 million today). That, in turn, would increase the density of electronic storage devices without increasing their physical size: 500 terabytes per square inch (compared to about 3 gigabytes now). No actual mention of iPods anywhere in the article. You just have to make the leap of assumption that someday this technology would be used in some future iPod so that you could store every song ever recorded.

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Tech News Link Dump

The title says it all…

The science journal Nature reports that this company in nearby Concord, NH has announced that they were able to produce the largest single sheet made up completely of carbon nanotubes. The sheet, which measures about 2 meters in length and 1 meter wide and is about as thick as a sheet of paper, has almost half the breaking strength of a similar-sized sheet of aluminum. The company says that they expect to find markets in companies that make EMI shielding, electrical conductors, and thermal dissipating devices. There’s probably some future use for materials like this in the space program, I would imagine.

Meanwhile, this story in EETimes says that a California company has announced that they’ve perfected a manufacturing process to make catalytic nanoparticles that could be used in place of metals in hydrogen fuel cells and other things that use electrolysis to produce energy. They claim that due to the vastly increased surface area created by using millions of nanoparticles, the efficiency of the electrolysis can be improved to 85%, besting the Department of Energy’s 75% efficiency 2010 goal for hydrogen fuel cells, and holds the potential of reaching an unheardof 96% efficiency. Efficiency of energy production is critical in taking alternative fuel technologies beyond the experimental stage, and the relative inefficiency of standard electrolysis has been a serious stumbling block for hydrogen-based fuel cells.

I recently received an Apple iPod Touch as a present. On one hand, it’s a serious fun gadget to have; we took it with us on our recent trip to New York City and used the Google Map location feature to find our way around all over Manhattan (thanks to all the unsecured wireless networks people have in NYC), as well as looking up restaurants, bus schedules, and other points of interest. On the other hand, the limitations built into the iPhone/iTouch by Apple are sometimes infuriating (no Flash player, no Windows support, etc). I will undoubtedly go the route of “jailbreaking” my iTouch in the very near future so that I can make use of some of the third-party apps that work when you wrest control from Steverino’s icy clutches.

I read this morning that Apple says it won’t prevent VoIP applications from working on the iPhone/iTouch, which means that I should be able to install Skype or some Skype-like application and add the ability to make phone calls from my otherwise phone-less iTouch. I purposely did not want an iPhone because I wasn’t interested in having to sign on for a 2-year contract with AT&T (or to have to try getting it to work with some other provider), but if I can use Skype, I definitely would give that a go.

I also came across this post at OpenCulture that says that all incoming freshmen at Abilene Christian University in Texas this fall will receive either an iPhone or an iTouch and be able to use the school’s online services via the device to check food service accounts, class schedules, look up faculty/staff directory information and eventually even register for classes and purchase textbooks. They’ll also have access to podcasts of their lecture classes, be able to submit homework, and potentially even participate in class by submitting questions in writing (though I think this means the professors need to brush up on their IM-speak to be able to read the questions). While most colleges and universities have computer requirements these days, and many of them give their students a computer, this is certainly an interesting step up from those kinds of programs.

Remember the satellite that the Navy shot down a couple of weeks ago? Space expert James Oberg posted this article at MSNBC debunking some of the rumors that have already emerged about the shootdown and clearing up some other technical misconceptions that were widely mentioned in the MSM.

Lastly, Science Daily reported that researchers at the University of Alberta have found that humans have a gene that is capable of preventing HIV from assembling inside cells, effectively shutting down the disease. However, the gene is “turned off” by default in our DNA. They don’t expect to be able to turn that gene “on” (might I suggest some soft music, flowers, and dancing?), but they do hope to be able to develop drugs that mimic the effect of the gene and could indeed halt the progression of HIV. If you’re the sort who likes to read this stuff for yourself, the full report can be found here. (I read the abstract, but gave up after that)

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